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Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto

United States Patent

January 7, 2003
View the Complete Patent at the US Patent & Trademark Office
A novel gene has been isolated which encodes cytochrome b5 (CYTb5) protein of the .omega.-hydroxylase complex of C. tropicalis 20336. Vectors including this gene, and transformed host cells are provided. Methods of increasing the production of a CYTb5 protein are also provided which involve transforming a host cell with a gene encoding this protein and culturing the cells. Methods of increasing the production of a dicarboxylic acid are also provided which involve increasing in the host cell the number of genes encoding this protein.
Craft; David L. (Fort Thomas, KY), Madduri; Krishna M. (Westfield, IN), Loper; John C. (Cincinnati, OH)
Cognis Corporation (Gulph Mills, PA)
09/ 912,161
July 24, 2001
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was funded, at least in part, under grants from the Department of Commerce, NIST-ATP Cooperative Agreement Number 70NANB8H4033 and the Department of Energy No. DE-FC36-95GO10099. The Government may therefore have certain rights in the invention.