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Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use

United States Patent

October 22, 2002
View the Complete Patent at the US Patent & Trademark Office
The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.
Nie; Shuming (Bloomington, IN), Chan; Warren C. W. (Bloomington, IN), Emory; Steven R. (Los Alamos, NM)
Advanced Research and Technology Institute, Inc. (Indianapolis, IN)
09/ 405,653
September 24, 1999
GOVERNMENT SUPPORT This invention was made, in part, with funding from the National Science Foundation under Grant No. CHE-9610254 and from the Department of Energy under Grant No. FG02-98ER14873. Therefore, the United States of America may have certain rights in the invention.