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Microfabricated AC impedance sensor

United States Patent

August 20, 2002
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A microfabricated instrument for detecting and identifying cells and other particles based on alternating current (AC) impedance measurements. The microfabricated AC impedance sensor includes two critical elements: 1) a microfluidic chip, preferably of glass substrates, having at least one microchannel therein and with electrodes patterned on both substrates, and 2) electrical circuits that connect to the electrodes on the microfluidic chip and detect signals associated with particles traveling down the microchannels. These circuits enable multiple AC impedance measurements of individual particles at high throughput rates with sufficient resolution to identify different particle and cell types as appropriate for environmental detection and clinical diagnostic applications.
Krulevitch; Peter (Pleasanton, CA), Ackler; Harold D. (Sunnyvale, CA), Becker; Frederick (Houston, TX), Boser; Bernhard E. (Berkeley, CA), Eldredge; Adam B. (Austin, TX), Fuller; Christopher K. (Livermore, CA), Gascoyne; Peter R. C. (Bellaire, TX), Hamilton; Julie K. (Tracy, CA), Swierkowski; Stefan P. (Livermore, CA), Wang; Xiao-Bo (San Diego, CA)
The Regents of the University of California (Oakland, CA)
09/ 704,355
November 1, 2000
The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.