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Micro-machined calorimetric biosensors

United States Patent

August 20, 2002
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.
Doktycz; Mitchel J. (Knoxville, TN), Britton, Jr.; Charles L. (Alcoa, TN), Smith; Stephen F. (Loudon, TN), Oden; Patrick I. (Plano, TX), Bryan; William L. (Knoxville, TN), Moore; James A. (Powell, TN), Thundat; Thomas G. (Knoxville, TN), Warmack; Robert J. (Knoxville, TN)
U T Battelle, LLC (Oak Ridge, TN)
09/ 395,630
September 14, 1999
STATEMENT OF GOVERNMENT RIGHTS This invention was made with Government support under Contract Number DE-AC05-96OR22464 awarded by the United States Department of Energy to Lockheed Martin Energy Research Corporation and the Government has certain rights in this invention.