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Photoacoustic removal of occlusions from blood vessels

United States Patent

August 6, 2002
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.
Visuri; Steven R. (Livermore, CA), Da Silva; Luiz B. (Danville, CA), Celliers; Peter M. (Berkeley, CA), London; Richard A. (Orinda, CA), Maitland, IV; Duncan J. (Lafayette, CA), Esch; Victor C. (San Francisco, CA)
The Regents of the University of California (Oakland, CA), Endovasix, Inc. (Belmont, CA)
09/ 604,454
June 27, 2000
UNITED STATES GOVERNMENT RIGHTS The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.