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Utilization of nuclear structural proteins for targeted therapy and detection of proliferative and differentiation disorders

United States Patent

September 11, 2001
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The localization of nuclear apparatus proteins (NUMA) is used to identify tumor cells and different stages in the tumor progression and differentiation processes. There is a characteristic organization of NuMA in tumor cells and in phenotypically normal cells. NuMA distribution patterns are significantly less diffuse in proliferating non-malignant cells compared to malignant cells. The technique encompasses cell immunostaining using a NuMA specific antibody, and microscopic analysis of NuMA distribution within each nucleus.
Lelievre; Sophie (Berkeley, CA), Bissell; Mina (Berkeley, CA)
The Regents of the University of California (Oakland, CA)
09/ 452,294
November 30, 1999
STATEMENT REGARDING FEDERAL SPONSORSHIP This invention was made with U.S. Government support under Contract No. DE -AC03-76SF0098 between the U.S. Department of Energy and the University of California for the operation of Lawrence Berkeley National Laboratory (LBNL). The U. S. Government may have certain rights to this invention.