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Compositions for boron delivery to mammalian tissue

United States Patent

August 14, 2001
View the Complete Patent at the US Patent & Trademark Office
Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.
Hawthorne; M. Frederick (Encino, CA), Feaks; Debra Arlene (Los Angeles, CA), Shelly; Kenneth John (Los Angeles, CA)
Reagents of the University of California (Oakland, CA)
09/ 280,098
March 29, 1999
This invention was made with support under Grant Number DE-FG03-95ER 61975 from the Department of Energy. Accordingly, the U.S. Government has certain rights in the invention.