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8-fluoropurine compounds

United States Patent

July 17, 2001
View the Complete Patent at the US Patent & Trademark Office
An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.
Barrio; Jorge R. (Agoura Hills, CA), Satyamurthy; Nagichettiar (Los Angeles, CA), Namavari; Mohammad (Los Angeles, CA), Phelps; Michael E. (Encino, CA)
The Regents of Univ. of California (Oakland, CA)
09/ 199,975
November 25, 1998
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This invention was made with government support under Grant No. DE-FC0387-ER60615, awarded by the Department of Energy. The government has certain rights in the invention.