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Microbial methods of reducing technetium

United States Patent

April 17, 2001
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
The present invention is directed toward a method for microbial reduction of a technetium compound to form other compounds of value in medical imaging. The technetium compound is combined in a mixture with non-growing microbial cells which contain a technetium-reducing enzyme system, a stabilizing agent and an electron donor in a saline solution under anaerobic conditions. The mixture is substantially free of an inorganic technetium reducing agent and its reduction products. The resulting product is Tc of lower oxidation states, the form of which can be partially controlled by the stabilizing agent. It has been discovered that the microorganisms Shewanella alga, strain Bry and Shewanelia putrifacians, strain CN-32 contain the necessary enzyme systems for technetium reduction and can form both mono nuclear and polynuclear reduced Tc species depending on the stabilizing agent.
Wildung; Raymond E. (Richland, WA), Garland; Thomas R. (Greybull, WY), Gorby; Yuri A. (Richland, WA), Hess; Nancy J. (Benton City, WA), Li; Shu-Mei W. (Richland, WA), Plymale; Andrew E. (Richland, WA)
Battelle Memorial Institute (Richland, WA)
09/ 398,834
September 16, 1999
This invention was made with Government support under Contract DE-AC0676RL01830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.