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Method for construction of bacterial strains with increased succinic acid production

United States Patent

December 12, 2000
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
A fermentation process for producing succinic acid is provided comprising selecting a bacterial strain that does not produce succinic acid in high yield, disrupting the normal regulation of sugar metabolism of said bacterial strain, and combining the mutant bacterial strain and selected sugar in anaerobic conditions to facilitate production of succinic acid. Also provided is a method for changing low yield succinic acid producing bacteria to high yield succinic acid producing bacteria comprising selecting a bacterial strain having a phosphotransferase system and altering the phosphotransferase system so as to allow the bacterial strain to simultaneously metabolize different sugars.
Donnelly; Mark I. (Warrenville, IL), Sanville-Millard; Cynthia (Plainfield, IL), Chatterjee; Ranjini (Park Ridge, IL)
University of Chicago (Chicago, IL)
09/ 067,931
April 28, 1998
CONTRACTUAL ORIGIN OF THE INVENTION The U.S. Government has rights in this invention under Contract No. W-31-109-ENG-38 between the U.S. Department of Energy and the University of Chicago representing Argonne National Laboratory.