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4-cyano-3-hydroxybutanoyl hydrazines, derivatives and process for the preparation thereof

United States Patent

September 5, 2000
View the Complete Patent at the US Patent & Trademark Office
Novel 4-cyano-3-hydroxybutanoyl hydrazides (10), particularly R-chiral intermediates are described. The intermediates are useful in preparing (R)-3-hydroxy-4-trimethylaminobutyric acid (L-carnitine) and R-4-amino-3-hydroxybutyric acid (GABOB) and chiral chemical intermediates which are medically useful.
Hollingsworth; Rawle I. (Haslett, MI), Wang; Guijun (East Lansing, MI)
Board of Trustees Operating Michigan State University (East Lansing, MI)
09/ 317,398
May 24, 1999
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with Department of Energy support under Grant No. DE-FG02-89ER14029. The government has certain rights in the invention.