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Method for high specific bioproductivity of .alpha.,.omega.-alkanedicarboxylic acids

United States Patent

May 23, 2000
View the Complete Patent at the US Patent & Trademark Office
This invention provides a low-cost method of producing .alpha.,.omega.-alkanedicarboxylic acids. Particular bioconversion conditions result in highly efficient conversion of fatty acid, fatty acid ester, or alkane substrates to diacids. Candida tropicalis AR40 or similar yeast strains are grown in a medium containing a carbon source and a nitrogen source at a temperature of C. to C., while additional carbon source is continuously added, until maximum cell growth is attained. Within 0-3 hours of this point, substrate is added to the culture to initiate conversion. An .alpha.,.omega.-alkanedicarboxylic acid made according to this method is also provided.
Mobley; David Paul (Schenectady, NY), Shank; Gary Keith (Rocky Hill, CT)
General Electric Company (Schenectady, NY)
09/ 157,669
September 21, 1998
This invention was made with Government support under Government Contract No. DE-FC36-95G010099, awarded by the Department of Energy. The Government has certain rights in this invention.