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Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids

United States Patent

June 15, 1999
View the Complete Patent at the US Patent & Trademark Office
A composition for inactivating a target nucleic acid which comprises an oligonucleoside alkyl or arylphosphonate analogue which is complementary to the sequence of the target nucleic acid and includes a functional group which reacts with the target nucleic acid to render the target nucleic acid inactive or nonfunctional.
Miller; Paul S. (Baltimore, MD), Ts'o; Paul O.P. (Lutherville, MD)
The Johns Hopkins University (Baltimore, MD)
08/ 342,005
November 16, 1994
The work disclosed herein was supported by grants from the National Institute of Health and the Department of Energy.