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Uses of Ku70

United States Patent Application

*** PATENT GRANTED ***
20030096262
6,808,887
A1
View the Complete Application at the US Patent & Trademark Office
This invention provides a method of diagnosing a predisposition to cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and; (b) determining whether one or more of the subject's Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subject's expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: (a) obtaining a nucleic acid sample from the subject; and (b) determining whether one or more of the subject's Ku70 alleles or regulatory regions to those alleles are deleted or different from the wild type so as to reduce or eliminate the subject's expression of polypeptide having tumor suppressor activity. This invention also provides a method of assessing the severity of cancer in a subject comprising: determining the subcellular localization of Ku70 in the subject, wherein an abnormal subcellular localization of Ku70 indicates a predisposition to cancer.
Li, Gloria C. (New York, NY), Cordon-Cardo, Carlos (New York, NY), Ouyang, Honghai (West Windsor, NJ)
10/ 161,025
June 3, 2002
[0002] The invention disclosed herein was made with Government support under NIH Grant Nos. CA-31397 and CA-56909 from the Department of Health and Human Services and the Department of Energy OHER (DC). Accordingly, the U.S. Government has certain rights in this invention.