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Use of generic oligonucleotide microchips to detect protein-nucleic acid interactions

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
Nucleic acids or proteins immobilized in a gel pad are interacting with a protein and the nucleic acid-protein and protein-protein interactions are characterized and measured. Large-scale, parallel measurements of these interactions can be examined to provide a powerful tool in elucidating interactions between proteins and nucleic acids.
Krylov, Alexander S. (Moscow, RU), Mirzabekov, Andrei (Moscow, RU), Prokopenko, Dmitry V. (Moscow, RU), Zasedateleva, Olga A. (Moscow, RU)
The University of Chicago
10/ 035,042
December 27, 2001
[0002] This invention was made with Government support under Contract No. W-31-109-ENG-38 awarded by the Department of Energy. The Government has certain rights in this invention.