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Use of a selectively inactivatable enzyme to digest contaminating nucleic acid

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Methods and kits for rendering inert contaminating nucleic acids are provided. The methods and kits include an enzyme capable of digesting the contaminating nucleic acids, an activator which activates the enzyme, and an inactivating agent capable of binding to or displacing the activator from the enzyme thus rendering the enzyme inactive.
Tabor, Stanley (Brookline, MA), Richardson, Charles C. (Newton, MA)
President and Fellows of Harvard College (Cambridge MA)
10/ 146,872
May 15, 2002
[0002] This invention was made with Government support under Grant Number DE-FG02-96ER62251 awarded by the Department of Energy and Grant Number GM54397-36 awarded by the National Institutes of Health. The Government has certain rights in the invention.