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Oncoprotein protein kinase

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
An isolated polypeptide (JNK characterized by having a molecular weight of 46 kD as determined by reducing SDS-PAGE, having serine and threonine kinase activity, phosphorylating the c-Jun N-terminal activation domain and polynucleotide sequences and method of detection of JNK are provided herein. JNK phosphorylates c-Jun N-terminal activation domain which affects gene expression from AP-1 sites.
Karin, Michael (San Diego, CA), Hibi, Masahiko (San Diego, CA), Lin, Anning (La Jolla, CA)
The Regents of the University of California
10/ 051,989
January 16, 2002
[0002] This invention was made with support by Howard Hughes Medical Institute and Government support under Grant No. DE-86ER60429, awarded by the Department of Energy and Grant No. CA-50528 and CA-58396, awarded by the National Institute of Health. The Government has certain rights in this invention. Also supported by the Howard Hughes Medical Institute.