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Compositions and Methods for Modulating DNA Repair

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Compositions and methods for modulating a DNA repair process in vivo or in vitro are provided. One aspect of the disclosure provides a pharmaceutical composition including a DNA repair modulator. The DNA repair modulator includes, but is not limited to, compositions such as polypeptides, for example antibodies; modified polypeptides; and branched or unbranched aliphatic, cycloaliphatic, substituted aliphatic, aromatic hydrocarbons, or heterocyclic carbon-based compounds that associate with a DNA repair polypeptide, for example, DNA-PKcs.
Dynan, William S. (Martinez, GA), Li, Shuyi (Martinez, GA), Takeda, Yoshihiko (Martinez, GA)
12/ 103,573
April 15, 2008
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] Aspects of the work described herein were supported, in part, by grant numbers GM35866 awarded by the National Institutes of Health and DE-FG07-99ER62875 awarded by the U.S. Department of Energy. Therefore, the U.S. government has certain rights in the invention.