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Lipid bilayers on nanotextured solid surfaces

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
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The present disclosure provides various novel suspended planar lipid bilayer assemblies made from bicellar mixtures containing long and short chain phospholipids and methods of making the same. Such bilayer assemblies may additionally incorporate biomolecules such as proteins, polypeptides, biological complexes, transmembrane proteins and other membrane-associated compounds. The present disclosure further provides uses for such lipid bilayer assemblies including proteomics, membrane study, biosensing for medical diagnosis and environmental monitoring, chemical and biological warfare agent sequestration, actuator development, and bio-fuel cell development.
Lopez, Gabriel (Albuquerque, NM), Zeineldin, Reema (Albuquerque, NM), Sasaki, Darryl (Livermore, CA), Last, Julie (Madison, WI)
11/ 796,038
April 26, 2007
STATEMENT REGARDING GOVERNMENT SPONSORED RESEARCH [0002] Aspects of this work were supported by a grant from the Department of the Army through Grant No. DAAD19-03-1-0173; by the National Science Foundation through Grant Nos. CTS 0332315; EEC 0210835; and CTS 04041224; and with support under Contract No. DE-AC04-94AL85000 from the Department of Energy. The United States Government has certain rights in the subject matter.