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Method for Detecting Alzheimer's Disease and other Forms of Dementia, and Measuring Their Progression

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The invention provides a method for detecting or monitoring Alzheimer's disease and other forms of dementia using positron emission tomography (PET) or single-photon emission computed tomagraphy (SPECT) and radiolabeled, serotonin 5-HT.sub.1A receptor-specific tracers (such as [F-18]MPPF, [F-18]FCWAY, [C-11]WAY-100635, and other radiolabeled compounds having agonistic or antagonistic effect on serotonin receptors), for detection or monitoring of pathological changes (i.e., neuronal cell loss) associated with dementia.
Barrio, Jorge R. (Agoura Hills, CA), Kepe, Vladimir (Los Angeles, CA), Small, Gary W. (Los Angeles, CA)
11/ 579,763
May 9, 2005
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT [0002] This invention was made with Government support, Grant No. DE-FC03-02ER63420, awarded by the Department of Energy. The Government has certain rights in the invention.