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DEVICES, SYSTEMS, AND METHODS FOR DETECTING NUCLEIC ACIDS USING SEDIMENTATION

United States Patent Application

20180065118
A1
View the Complete Application at the US Patent & Trademark Office
Embodiments of the present invention are directed toward devices, systems, and method for conducting nucleic acid purification and quantification using sedimentation. In one example, a method includes generating complexes which bind to a plurality of beads in a fluid sample, individual ones of the complexes comprising a nucleic acid molecule such as DNA or RNA and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
Koh, Chung-Yan (Dublin, CA), Schaff, Ulrich Y. (Livermore, CA), Sommer, Gregory J. (Livermore, CA)
15/ 704,860
September 14, 2017
STATEMENT REGARDING RESEARCH & DEVELOPMENT [0002] Described examples were made with Government support under Contract No. DE-NA0003525 awarded by the United States Department of Energy/National Nuclear Security Administration. The Government has certain rights in the invention, including a paid-up license and the right, in limited circumstances, to require the owner of any patent issuing in this invention to license others on reasonable terms.