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Host Cells and Methods for Production of Isobutanol

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Provided herein are recombinant yeast host cells and methods for their use for production of isobutanol. Yeast host cells provided comprise an isobutanol biosynthetic pathway and at least one of reduced or eliminated aldehyde dehydrogenase activity, reduced or eliminated acetolactate reductase activity; or a heterologous polynucleotide encoding a polypeptide having ketol-acid reductoisomerase activity.
Anthony, Larry Cameron (Aston, PA), HE, Hongxian (Wilmington, DE), HUANG, Lixuan Lisa (Hockessin, DE), O'KEEFE, Daniel P. (Ridley Park, PA), KRUCKBERG, Arthur Leo (Wilmington, DE), LI, Yougen (Pennington, NJ), MAGGIO-HALL, Lori Ann (Wilmington, DE), MCELVAIN, Jessica (Wilmington, DE), NELSON, Mark J. (Newark, DE), PATNAIK, Ranjan (Newark, DE), ROTHMAN, Steven Cary (Wilmington, DE)
15/ 477,980
April 3, 2017
GOVERNMENT LICENSE RIGHTS [0002] This invention was made with Government support under Agreement DE-AR0000006 awarded by the United States Department of Energy. The Government has certain rights in this invention.