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Orthogonal Cas9 Proteins for RNA-Guided Gene Regulation and Editing

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Methods of modulating expression of a target nucleic acid in a cell are provided including use of multiple orthogonal Cas9 proteins to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.
Church, George M. (Brookline, MA), Esvelt, Kevin M. (Auburnadle, MA), Mali, Prashant G. (Somerville, MA)
14/ 903,728
July 8, 2014
STATEMENT OF GOVERNMENT INTERESTS [0002] This invention was made with government support under Grant No. P50 HG005550 from the National Institutes of health and DE-FG02-02ER63445 from the Department of Energy. The government has certain rights in the invention.