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United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Disclosed herein are mosaic conserved region HIV polypeptides and immunogenic polypeptides including one or more of the mosaic conserved region polypeptides. In some embodiments, the immunogenic polypeptides are included in an immunogenic composition, such as a polyvalent immunogenic composition. Also disclosed herein are methods for treating or inhibiting HIV in a subject including administering one or more of the disclosed immunogenic polypeptides or compositions to a subject having or at risk of HIV infection. In some embodiments, the methods include inducing an immune response in a subject comprising administering to the subject at least one of the disclosed immunogenic polypeptides or a nucleic acid encoding at least one of the immunogenic polypeptides.
Korber, Bette T.M. (Los Alamos, NM), Hanke, Tomas (Oxford, GB), McMichael, Andrew (Oxford, GB)
Los Alamos National Security, LLC (Los Alamos NM), Isis Innovation Limited (Oxfored)
15/ 025,733
September 30, 2014
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT [0002] This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy and grant number AI100645 from the National Institutes of Health. The government has certain rights in the invention.