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Method of treating tumors

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
A method of treating tumors, such as prostate tumors, breast tumors, non-Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo-arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.
DeNardo, Sally J. (El Macerco, CA), Burke, Patricia A. (Sacramento, CA), DeNardo, Gerald L. (El Macerco, CA), Goodman, Simon (Darmstadt, DE), Matzku, Siegfried (Zwingenberg, DE), Matzku, Kerstin (Zwingenberg, DE)
The Regents of the University of California, Merck Patent GmbH
11/ 378,093
March 17, 2006
STATEMENT OF GOVERNMENT INTEREST [0002] A portion of the work described herein was supported by grant number PO1 CA-47829 from the National Cancer Institute, and by grants number DEFG01-00NE22944 and DEFG03-84ER60233 from the United States Department of Energy. The United States Government has certain rights in this invention.