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METHOD OF TISSUE REPAIR USING A COMPOSITE MATERIAL

United States Patent Application

*** PATENT GRANTED ***
20140205676
9,272,045
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young's modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.
Hutchens, Stacy A. (Knoxville, TN), Woodward, Jonathan (Solihull, GB), Evans, Barbara R. (Oak Ridge, TN), O'Neill, Hugh M. (Knoxville, TN)
University of Tennessee Research Foundation (Knoxville TN), UT-Battelle, LLC (Oak Ridge TN)
14/ 200,060
March 7, 2014
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] The United States Government has rights in this invention pursuant to Contract No. DE-AC05-00OR22725 between the United States Department of Energy and UT-Battelle, LLC.