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Magnetically Induced Microspinning for Super-Detection and Super-Characterization of Biomarkers and Live Cells

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Identification, quantification and characterization of biological micro- and nano-systems is enabled by magnetically spinning these natural, non-magnetic systems with the aid of induced magnetization. Biofriendly magnetic micro- and nano-labels enable magnetorotation in extremely weak electromagnetic fields. The spinning of these micromotors can be observed by a simple, CD-like, optical tracking system. The spinning frequency response enables real-time monitoring of single (cancer) cell morphology, with sub-microscopic resolution, yielding previously undeterminable information. Likewise, it enables super-low detection limits for any (cancer) biomarker.
Kopelman, Raoul (Ann Arbor, MI), Elbez, Remy (Ann Arbor, MI), Hecht, Ariel (Ann Arbor, MI), McNaughton, Brandon H. (Ann Arbor, MI)
The Regents of the University of Michigan (Ann Arbor MI)
14/ 111,142
April 11, 2012
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made, at least in part, with government support under Contract Nos. R21 EB009550 UL1 RR024986, R21 EB009550, and R33CA125297 awarded by the National Institutes of Health, Contract No. DOE DE-AC05-060R23100 awarded by the Department of Energy and Contract No. DMR0455330 awarded by the National Science Foundation. The U.S. government may have certain rights in this invention.