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Rapid haplotyping by single molecule detection

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The present invention includes a method for rapid haplotyping a DNA or RNA segment. Two or more target sites on a segment of DNA or RNA are labeled with separate distinguishable luminescent hybridization probes, where the targets are selected genetic markers. A dilute solution is formed containing the labeled DNA or RNA segments. Each DNA or RNA segment is illuminated with light beams effective to excite each luminescent hybridization probe, when present. The presence or absence of each luminescent hybridization probe on each DNA or RNA segment is detected to determine the haplotype of each DNA or RNA segment.
Cai, Hong (Los Alamos, NM), Goodwin, Peter M. (Los Alamos, NM), Keller, Richard A. (Los Alamos, NM), Werner, James H. (Los Alamos, NM)
09/ 862,855
May 21, 2001
STATEMENT REGARDING FEDERAL RIGHTS [0002] This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.