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Hybridization and sequencing of nucleic acids

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Devices and techniques for hybridization of nucleic acids and for determining the sequence of nucleic acids. Arrays of nucleic acids are formed by techniques, preferably high resolution, light-directed techniques. Positions of hybridization of a target nucleic acid are determined by, e.g., epifluorescence microscopy. Devices and techniques are proposed to determine the sequence of a target nucleic acid more efficiently and more quickly through such synthesis and detection techniques.
Fodor, Stephen P.A. (Palo Alto, CA), Lipshutz, Robert J. (Palo Alto, CA), Huang, Xiaohua (Mt. View, CA)
10/ 985,032
November 10, 2004
[0001] The invention described herein arose in the course of or under Contract No. DE-FG03-92ER81275 (Grant No. 21012-92-II) between the Department of Energy and Affymax; and in the course of or under NIH Contract No. 1R01HG00813-01.