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Host Cells and Methods for Producing Fatty Acid

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a genetically modified host cell capable of producing fatty acid comprising an increased expression of FadR, or a functional variant thereof. The host cell under environmental conditions wherein fatty acid is produced expresses an increased amount of FadR when compared to an unmodified host cell. The present invention also provides for a method of producing a fatty acid or FAAE in the host cell. The present invention provides for a genetically modified host cell comprising a fatty acid biosensor and one or more fatty acid-responsive promoter operably linked to one or more genes of interest that is heterologous to the fatty acid-responsive promoter.
Zhang, Fuzhong (Ontario, CA), Steen, Eric J. (San Francisco, CA), Keasling, Jay D. (Berkeley, CA)
13/ 549,034
July 13, 2012
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention described and claimed herein was made utilizing funds supplied by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.