Skip to Content
Find More Like This
Return to Search

Dual Chain Synthetic Heparin-Binding Growth Factor Analogs

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
Zamora, Paul O. (Gaithersburg, MD), Pena, Louis A. (Poquott, NY), Lin, Xinhua (Plainview, NY)
13/ 454,933
April 24, 2012
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made with United States Government support under contract number DE-ACO2-98CH10886, awarded by the U.S. Department of Energy. The United States Government has certain rights in the invention.