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Methods Employing McrA to Detect 5-Methyl Cytosine

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The invention provides methods for using the rMcrA protein, and derivatives thereof, for direct or semi-direct determination of the methylation status of CpG dinucleotides in methyl-CpG island sequences of interest.
Dunn, John J. (Bellport, NY), Hatchwell, Eli (Winchester, GB)
Brookhaven Science Associates, LLC (Upton NY)
13/ 323,962
December 13, 2011
[0002] This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy and sponsored in part by NIH grant 1U01A1056480-05. The Government has certain rights in the invention.