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Production of human coagulation factor VIII from plant cells and whole plants

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
The invention includes methods for production of a polypeptide having factor VIII activity by introduction of a polynucleotide construct into a plant cell. The construct includes an encoding sequence for a polypeptide of coagulation factor VIII or a functional variant thereof. The plant cell is cultured or regenerated into a plant and the polypeptide or functional variant of factor VIII is expressed therein. The invention also includes vectors, plant cells, plant tissues, plants and seeds containing a polynucleotide sequence encoding a functional variant of human coagulation factor VIII. The invention further includes a recombinant DNA molecule having a promoter which is functional in plants operably linked to a coding sequence which codes for a polynucleotide having coagulation factor VIII activity.
Hooker, Brian S. (Kennewick, WA), Anderson, Daniel B. (Pasco, WA), Gao, Johnway (Richland, WA), Dai, Ziyu (Richland, WA)
10/ 863,969
June 8, 2004
[0002] This invention was made with Government support under Contract DE-AC06 76RLO 1830 awarded by the United States Department of Energy. The Government has certain rights in the invention.