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Method for fabrication of biochips with a macroporous polymer substrate

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
Macroporous polymer substrates have greater immobilization capacity for large biomolecules and better access for analytes than substrates used previously for microarrays. Microarrays are fabricated with macroporous polymer substrates, and nucleic acids, proteins and peptides are immobilized in the substrate. Microarrays with macroporous polymer substrates are useful in immunoassays, drug discovery studies and other biotechnological applications that involve large scale macromolecular interactions. Nucleic acid hybridizations, protein binding, and antigen-antibody interactions are analyzed using microarrays with macroporous polymer substrates.
Kukhtin, Alexander V. (Lockport, IL), Chernov, Boris K. (Willowbrook, IL), Golova, Julia B. (Willowbrook, IL), Yershov, Gennadiy M. (Willowbrook, IL), Gemmell, Margaret Anne (Western Springs, IL)
10/ 642,768
August 18, 2003
[0001] The United States Government has rights in this invention pursuant to Contract No. W-31-109-ENG-38 between the U.S. Department of Energy (DOE) and the University of Chicago representing Argonne National Laboratory