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Matrix for MALDI analysis based on porous polymer monoliths

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The use of porous monolithic matrix for matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis on a sample suspected of containing an analyte is herein described. The porous polymer monoliths provide a matrix suitable for use in detecting and analyzing low molecular weight and small molecules. The matrices described herein also facilitate the creation of arrays of monolithic matrices for high-throughput detection and screening using MALDI-TOF mass spectrometry and exhibit a long shelf-life.
Frechet, Jean M.J. (Oakland, CA), Svec, Frantisek (Alameda, CA), Peterson, Dominic S. (Los Alamos, NM), Luo, Quanzhou (Richland, WA)
The Regents of the University of California (Oakland CA)
10/ 866,225
June 9, 2004
[0002] This work was supported by the U.S. Department of Energy under Contract No. DE-AC03-76SF00098. The government has certain rights in this invention.