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Apparatuses for Detecting and Recognizing Analytes Based on Their Crystallization Patterns

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The invention contemplates apparatuses for recognition of proteins and other biological molecules by imaging morphology, size and distribution of crystalline and amorphous dry residues in droplets (further referred to as "crystallization patterns") containing predetermined amount of certain crystal-forming organic compounds (reporters) to which protein to be analyzed is added. Changes in the crystallization patterns of a number of amino-acids can be used as a "signature" of a protein added. Also, changes in the crystallization patterns, as well as the character of such changes, can be used as recognition elements in analysis of protein molecules.
Morozov, Victor (Manassas, VA), Bailey, Charles L. (Cross Junction, VA), Vsevolodov, Nikolai N. (Kensington, MD), Elliott, Adam (Manassas, VA)
12/ 941,650
January 19, 2011
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of DOE Grant No. DE-F C52-04NA25455 awarded by the U.S. Department of Energy.