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METHODS FOR TARGETTED MUTAGENESIS IN GRAM-POSITIVE BACTERIA

United States Patent Application

*** PATENT GRANTED ***
20100075303
8,735,160
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
The present invention provides a method of targeted mutagenesis in Gram-positive bacteria. In particular, the present invention provides a method that effectively integrates a suicide integrative vector into a target gene in the chromosome of a Gram-positive bacterium, resulting in inactivation of the target gene.
YANG, Yunfeng (Oak Ridge, TN)
UT-Battelle, LLC (Oak Ridge TN)
12/ 233,806
September 19, 2008
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0001] This invention was made with Government support under Contract No. DE-AC05-000R22725 awarded by the United States Department of Energy. The Government has certain rights in this invention.