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Species specific identification of spore-producing microbes using the gene sequence of small acid-soluble spore coat proteins for amplification based diagnostics

United States Patent Application

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The present invention relates to methods and compositions for the detection of Bacillus species such as Bacillus anthracis and Bacillus globigii as well as Clostridium perfringens. It relies on nucleic acid sequence differences in spore protein genes carried in the genomic sequence of these organisms.
Hunter-Cevera, Jennifer C. (Ellicott City, MD), Leighton, Terrance (Lafayette, CA), Goldman, Stan (Walnut Creek, CA), Longchamp, Pascal (Palo Alto, CA), McKinney, Nancy (La Honda, CA)
10/ 067,613
February 4, 2002
[0002] This invention was made under work supported by the U.S. Department of Energy under DOE Contract No.: DE-AC03-76SF00098. The government has certain rights in this invention.