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Method for detecting macromolecular conformational change and binding information

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
An active-nucleus sensor or a functionalized active-nucleus complex sensor is utilized in a method for detecting conformational change and binding event information in a targeted molecule, wherein the sensor does not participate in the conformational change or binding event. The method directly or indirectly detects the occurrence, deletion, shift, or any measurable change in a magnetic resonance signal with a unique magnetic resonance property from the active-nuclei, frequently hyperpolarized .sup.129Xe.
Pines, Alexander (Berkeley, CA), Wemmer, David E. (Berkeley, CA), Spence, Megan (Zurich, CH), Rubin, Seth (Albany, CA), Ruiz, E. Janette (Berkeley, CA), Dimitrov, Ivan E. (North Wales, PA)
10/ 268,973
October 9, 2002
[0004] This invention was made with Government support under Contract No. DE-AC03-76SF00098 awarded by the Department of Energy, Grant No. RR02305 awarded by National Institutes of Health, and Contract No. N0001498F0402 MDI-II awarded by the Office of Naval Research. The Government has certain rights in this invention.