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Novel apolipoprotein gene involved in lipid metabolism

United States Patent Application

*** PATENT GRANTED ***
20030150003
7,238,475
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods and materials for studying the effects of a newly identified human gene, APOAV, and the corresponding mouse gene apoAV. The sequences of the genes are given, and transgenic animals which either contain the gene or have the endogenous gene knocked out are described. In addition, single nucleotide polymorphisms (SNPs) in the gene are described and characterized. It is demonstrated that certain SNPs are associated with diseases involving lipids and triglycerides and other metabolic diseases. These SNPs may be used alone or with SNPs from other genes to study individual risk factors. Methods for intervention in lipid diseases, including the screening of drugs to treat lipid-related or diabetic diseases are also disclosed.
Rubin, Edward (Berkeley, CA), Pennacchio, Len A. (Sebastopol, CA)
10/ 229,834
August 27, 2002
[0002] This invention was made during work supported in part by the U.S. Department of Energy, Office of Biological and Environmental Research, under Contract No. DE-AC03-76SF00098. The government has certain rights in this invention.