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Giga-Dalton Mass Spectrometry

Major leap forward for Mass Spectrometry Applications to Life Sciences

Oak Ridge National Laboratory

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Technology Marketing SummaryCurrent techniques to study large bio?molecules using mass spectrometer require fragmentation for the mass?to?charge ratios to be within the working range of the mass spectrometer. Analysis of the data is complex and often requires simulation supported by fragmentation libraries. Furthermore, the working range of the mass spectrometer is limited to the Kilo?Dalton range and offered by high end expensive instruments. These are major limiting factors in the applications of mass spectrometry for analyzing viruses or large bio?molecules that are typically in the Mega to Giga Dalton mass range.


DescriptionScientists at ORNL have developed a system for mass spectrometry that allows intact large molecules to be mass analyzed. In addition, this system increases the working range of the mass spectrometer by at least a six orders of magnitude into the Giga??Dalton mass range. This system has been used to analyze individual, singly charged proteins, such as Myosin (a ~ 200 Kilo?Dalton protein), and has observed nanoparticles of urea and polystyrene latex beads that are in the Giga?Dalton range.Benefits
  • High resolution mass analysis of intact proteins, viruses and other massive biological species
  • Increases the working range of the mass spectrometer into Giga?Dalton mass range while maintaining mass resolution
Applications and IndustriesThe working range of current mass spectrometers are limited to the Kilo?Dalton range, which limits the applications of mass spectrometry for analyzing viruses or large bio?molecules that are typically in the Mega to Giga Dalton mass range.More InformationPatents: Ultra High Mass Range Mass Spectrometer Systems (UTB – ID 1723, UTB – ID 1871 and UTB – ID 1305) , US Patent 6,972,408

Lead Inventor
Dr. Peter Reilly
Patents and Patent Applications
ID Number
Title and Abstract
Primary Lab
Date
Patent 6,972,408
Patent
6,972,408
Ultra high mass range mass spectrometer systems
Applicant's present invention comprises mass spectrometer systems that operate in a mass range from 1 to 10.sup.16 DA. The mass spectrometer system comprising an inlet system comprising an aerodynamic lens system, a reverse jet being a gas flux generated in an annulus moving in a reverse direction and a multipole ion guide; a digital ion trap; and a thermal vaporization/ionization detector system. Applicant's present invention further comprises a quadrupole mass spectrometer system comprising an inlet system having a quadrupole mass filter and a thermal vaporization/ionization detector system. Applicant's present invention further comprises an inlet system for use with a mass spectrometer system, a method for slowing energetic particles using an inlet system. Applicant's present invention also comprises a detector device and a method for detecting high mass charged particles.
Oak Ridge National Laboratory 12/06/2005
Issued
Technology Status
Technology IDDevelopment StageAvailabilityPublishedLast Updated
1723, 1871 and 1305DevelopmentAvailable09/24/201209/24/2012

Contact ORNL About This Technology

To: Jennifer Tonzello Caldwell, Ph.D.<pftt@ornl.gov>