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Molecule Nanoweaver Improves Drug Delivery and Treatment Efficacy

Argonne National Laboratory

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<p>
	Schematic of molecular assembly using molecule nanoweaver. The figure illustrates one of many (general) protocols or processes for creating a film tailored at the nanoscale, but overall having macroscale dimensions. The protocol includes <em>in situ</em> monitoring at every step along the synthetic route by using the powerful tool of solid-state NMR analyses. Upon development of a mature protocol, the Molecule Nanoweaver would operate on an assembly line independent of expensive analytical NMR capabilities.</p>

Schematic of molecular assembly using molecule nanoweaver. The figure illustrates one of many (general) protocols or processes for creating a film tailored at the nanoscale, but overall having macroscale dimensions. The protocol includes in situ monitoring at every step along the synthetic route by using the powerful tool of solid-state NMR analyses. Upon development of a mature protocol, the Molecule Nanoweaver would operate on an assembly line independent of expensive analytical NMR capabilities.

Technology Marketing Summary

The ability to tailor medical patches and capsules at the molecular level offers a game-changing approach to medical treatment and drug delivery. With each molecule positioned for optimal effectiveness, patches and capsules can be improved and customized for a variety of purposes.

Description

Because MRI scans rely on the use of a strong magnetic field, the presence of metal in a patient’s body can interfere with the technology and even rule out imaging. A research team at Argonne National Laboratory has manipulated the technology so that such metal objects become a detection system—in essence, allowing them to go unnoticed by the magnetic field.

Applying their findings in MRI technology has enabled the researchers to create other ground-breaking innovations, among them a device called the Molecule Nanoweaver. This unique tool can be used as both a fabricator and a detector of high-tech patches, multilayered capsules and other medical products.

As a fabricator, the nanoweaver can produce patches, capsules and other products by using electric, magnetic and intermolecular forces to manipulate molecules into useful patterns. As a detector, the nanoweaver’s spectroscopy and imaging capabilities allow the user to follow the process closely to ensure that fabrication proceeds correctly. For example, the Molecule Nanoweaver could be used to optimize and produce a heart-muscle stimulator patch that provides low-level electrical stimulation from electrochemical reactions taking place in the patch material.

Benefits
  • Revolutionizes the development of a wide range of medical products, including patches, capsules and others.
  • Provides greater precision and control at the molecular level of the manufacturing process, enabling optimal functionality.
  • Capable of setting up interactions between different molecules to attain unique medical functionalities.
  • Facilitates the development of sophisticated, customized drugs and products able to speed up the healing process.
Applications and Industries

This innovation has applications for the medical devices, biotechnology and pharmaceuticals industries.

Patents and Patent Applications
ID Number
Title and Abstract
Primary Lab
Date
Patent 7,501,483
Patent
7,501,483
Molecule nanoweaver
A method, apparatus, and system for constructing uniform macroscopic films with tailored geometric assemblies of molecules on the nanometer scale. The method, apparatus, and system include providing starting molecules of selected character, applying one or more force fields to the molecules to cause them to order and condense with NMR spectra and images being used to monitor progress in creating the desired geometrical assembly and functionality of molecules that comprise the films.
Argonne National Laboratory 03/10/2009
Issued
Technology Status
Development StageAvailabilityPublishedLast Updated
Development - Proof of conceptAvailable02/07/201202/07/2012

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To: Elizabeth Jordan<partners@anl.gov>