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The µChemLabTM: Bio Detector

Sandia National Laboratories

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Second-generation biotoxin detection system.
Second-generation biotoxin detection system.

Technology Marketing Summary

Sandia National Laboratories has developed a series of compact, hand-held detection systems that place the capability of a fully functional chemistry laboratory at the fingertips of a trained field operator. Sandia's chemical analysis system can rapidly detect and analyze toxic agents such as bacteria, viruses, and protozoa.

The µChemLabTM was designed, demonstrated, and tested by Sandia researchers over several years. The systems were initially developed for homeland security, defense applications, war fighters, and first responders. A variety of applications and near-term commercialization opportunities now exist in markets such as air and water quality, medical diagnostics, biotechnology, and industrial process control.

Description

The µChemLabTM Bio Detector is a portable device for determining the presence of a target analyte and enabling fast microfluidic separations of biological samples with high sensitivity. The device miniaturizes bench-scale analyses using fabricated microchannels in a hand-held, low-power device. Many different separations can be run simultaneously, and identification of the compound of interest is determined from unique retention-time signatures.

Designed for the rapid detection of proteins, the µChemLabTM has been used to identify biotoxins such as ricin, staphylococcal enterotoxin B, and botulinum toxin; its capability has been extended in combination with innovative, automated sample preparation technology to enable the identification of viruses and bacteria. Parallel analysis channels provide highly accurate detection at nanomolar sensitivites with a low false alarm probability.

Benefits
  • Hand-portable
  • Low power consumption
  • Rapid analyses (5 to 10 minutes)
  • Highly accurate detection at nanomolar sensitivities
  • Low false alarm rate
Applications and Industries
  • Identification of biotoxins such as ricin, staphylococcal enterotoxin B, and botulinum toxin
  • Identification of viruses and bacteria
  • Air and water quality testing, medical diagnostics, biotechnology, and industrial process control
  • Full amenability to DNA-based separations for sizing or fragment detection

      
The µChemLabTM was used for bioagent detection, for example, in the BioBriefcase program.

More Information

For more information:
http://www.sandia.gov/mission/homeland/chembio/development/detection/biobriefcase.html

Patents and Patent Applications
ID Number
Title and Abstract
Primary Lab
Date
Patent 7,452,507
Patent
7,452,507
Portable apparatus for separating sample and detecting target analytes
Portable devices and methods for determining the presence of a target analyte using a portable device are provided. The portable device is preferably hand-held. A sample is injected to the portable device. A microfluidic separation is performed within the portable device and at least one separated component detected by a detection module within the portable device, in embodiments of the invention. A target analyte is identified, based on the separated component, and the presence of the target analyte is indicated on an output interface of the portable device, in accordance with embodiments of the invention.
Sandia National Laboratories 11/18/2008
Issued
Patent 7,161,334
Patent
7,161,334
Modular high voltage power supply for chemical analysis
A high voltage power supply for use in a system such as a microfluidics system, uses a DC--DC converter in parallel with a voltage-controlled resistor. A feedback circuit provides a control signal for the DC--DC converter and voltage-controlled resistor so as to regulate the output voltage of the high voltage power supply, as well as, to sink or source current from the high voltage supply.
Sandia National Laboratories 01/09/2007
Issued
Patent 7,012,342
Patent
7,012,342
Low power, scalable multichannel high voltage controller
A low voltage control circuit is provided for individually controlling high voltage power provided over bus lines to a multitude of interconnected loads. An example of a load is a drive for capillary channels in a microfluidic system. Control is distributed from a central high voltage circuit, rather than using a number of large expensive central high voltage circuits to enable reducing circuit size and cost. Voltage is distributed to each individual load and controlled using a number of high voltage controller channel switches connected to high voltage bus lines. The channel switches each include complementary pull up and pull down photo isolator relays with photo isolator switching controlled from the central high voltage circuit to provide a desired bus line voltage. Switching of the photo isolator relays is further controlled in each channel switch using feedback from a resistor divider circuit to maintain the bus voltage swing within desired limits. Current sensing is provided using a switched resistive load in each channel switch, with switching of the resistive loads controlled from the central high voltage circuit.
03/14/2006
Issued
Patent 7,710,086
Patent
7,710,086
Modular high voltage power supply for chemical analysis
A high voltage power supply for use in a system such as a microfluidics system, uses a DC-DC converter in parallel with a voltage-controlled resistor. A feedback circuit provides a control signal for the DC-DC converter and voltage-controlled resistor so as to regulate the output voltage of the high voltage power supply, as well as, to sink or source current from the high voltage supply.
Sandia National Laboratories 05/04/2010
Issued
Patent 7,400,119
Patent
7,400,119
Modular high voltage power supply for chemical analysis
A high voltage power supply for use in a system such as a microfluidics system, uses a DC-DC converter in parallel with a voltage-controlled resistor. A feedback circuit provides a control signal for the DC-DC converter and voltage-controlled resistor so as to regulate the output voltage of the high voltage power supply, as well as, to sink or source current from the high voltage supply.
Sandia National Laboratories 07/15/2008
Issued
Technology Status
Technology IDDevelopment StageAvailabilityPublishedLast Updated
SD# 8412.1, SD# 8412.2PrototypeAvailable09/29/201110/31/2016

Contact SNL About This Technology

To: Technology Inquiries<ip@sandia.gov>