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pH-Sensitive Methacrylic Copolymer Gels

Ames Laboratory

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Technology Marketing Summary

Synthesis routes have been defined and materials have been produced, and ISU is seeking partners interested in commercializing this technology.

Description
 
Iowa State University and Ames Laboratory researchers have developed an invention which provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic( polymers, or a poly(ethylene glycol) polymer. The polymers may be use for drug and gene delivery, protein separation, as structural supplements, and more.
Benefits

These copolymers are water-soluble, pH sensitive and capable of thermoreversible gelation near physiological temperatures.

Applications and Industries

Drug delivery

Gene delivery

Protein separation

Structural supplements
More Information

Direct Link to ISURF Technology: http://isurftech.technologypublisher.com/technology/19578

Patents and Patent Applications
ID Number
Title and Abstract
Primary Lab
Date
Patent 7,217,776
Patent
7,217,776
pH-sensitive methacrylic copolymer gels and the production thereof
The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.
Ames Laboratory 05/15/2007
Issued
Technology Status
Technology IDDevelopment StageAvailabilityPublishedLast Updated
2954ProposedAvailable12/05/201712/05/2017

Contact AMES About This Technology

To: Dario Valenzuela<licensing@iastate.edu>