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SpinDx™ Lab on a Disk

Sandia National Laboratories

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PDF Document PublicationSpinDx Lab on a Disk- Summary Sheet  (1,289 KB)



Technology Marketing Summary

Currently, when a patient arrives at the hospital or doctor’s office feeling ill, they are first examined by the doctor, sent to a blood lab where vials of blood are taken, and then sent home to wait for results. This approach often means patients must wait days or weeks, to get results. During that waiting period, they are not receiving treatment, which can be a critical factor for cancer, heart attack, or stroke patients. 

Sandia researchers have developed a break-through technology which can test and diagnose up to 64 assays on a single disc within 15 minutes of sample collection. 

 

Description

This break-through technology requires significantly less blood (less than a pin-prick) than the current laboratory blood draw. This machine can revolutionize the way we will get test results from doctors offices and hospitals alike. Besides the inherent portability of the testing device, the assay discs can  be manufactured for pennies, making this an affordable option for both small and large practices with the potential to drive down the cost of testing, visits, and to shorten time-to-treatment.. This technology as has broad application beyond medical diagnostics; it can be broadly applied across food safety, over bio-terrorism detection, and commercial drug testing markets.

 

Benefits
  • Extremely fast—sample to results within 15 minutes
  • Ease of use—no sample prep required
  • Portable—easily taken into the field
  • Cost effective—disks cost less than 10 cents to manufacture
  • Multiplexing—up to 64 assays on a single disc

 

Applications and Industries
  • Point-of-Care Diagnostics (human and animal)
  • Food & Environmental Monitoring
  • Bio defense

 

Potential Testing
  • Multiplexed Immunoassays
  • Nucleic Acid Hybridization Assays
  • Differential Blood Cell Analysis

 

More Information

Types of Samples Processed

  • Bodily fluids—whole blood serum, saliva, urine
  • Environmental fluids—water
  • Food—soup, water, milk, etc.

 

 

Patents and Patent Applications
ID Number
Title and Abstract
Primary Lab
Date
Patent 9,304,129
Patent
9,304,129
Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.
Sandia National Laboratories 04/05/2016
Issued
Patent 8,962,346
Patent
8,962,346
Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation
Embodiments of the present invention are directed toward devices, systems, and method for conducting assays using sedimentation. In one example, a method includes layering a mixture on a density medium, subjecting sedimentation particles in the mixture to sedimentation forces to cause the sedimentation particles to move to a detection area through a density medium, and detecting a target analyte in a detection region of the sedimentation channel. In some examples, the sedimentation particles and labeling agent may have like charges to reduce non-specific binding of labeling agent and sedimentation particles. In some examples, the density medium is provided with a separation layer for stabilizing the assay during storage and operation. In some examples, the sedimentation channel may be provided with a generally flat sedimentation chamber for dispersing the particle pellet over a larger surface area.
Sandia National Laboratories 02/24/2015
Issued
Patent 8,945,914
Patent
8,945,914
Devices, systems, and methods for conducting sandwich assays using sedimentation
Embodiments of the present invention are directed toward devices, systems, and method for conducting sandwich assays using sedimentation. In one example, a method includes generating complexes on a plurality of beads in a fluid sample, individual ones of the complexes comprising a capture agent, a target analyte, and a labeling agent. The plurality of beads including the complexes may be transported through a density media, wherein the density media has a density lower than a density of the beads and higher than a density of the fluid sample, and wherein the transporting occurs, at least in part, by sedimentation. Signal may be detected from the labeling agents of the complexes.
Sandia National Laboratories 02/03/2015
Issued
Patent 9,186,668
Patent
9,186,668
Microfluidic devices, systems, and methods for quantifying particles using centrifugal force
Embodiments of the present invention are directed toward microfluidic systems, apparatus, and methods for measuring a quantity of cells in a fluid. Examples include a differential white blood cell measurement using a centrifugal microfluidic system. A method may include introducing a fluid sample containing a quantity of cells into a microfluidic channel defined in part by a substrate. The quantity of cells may be transported toward a detection region defined in part by the substrate, wherein the detection region contains a density media, and wherein the density media has a density lower than a density of the cells and higher than a density of the fluid sample. The substrate may be spun such that at least a portion of the quantity of cells are transported through the density media. Signals may be detected from label moieties affixed to the cells.
Sandia National Laboratories 11/17/2015
Issued
Patent 9,244,065
Patent
9,244,065
Systems, devices, and methods for agglutination assays using sedimentation
Embodiments of the present invention include methods for conducting agglutination assays using sedimentation. Aggregates may be exposed to sedimentation forces and travel through a density medium to a detection area. Microfluidic devices, such as microfluidic disks, are described for conducting the agglutination assays, as are systems for conducting the assays.
Sandia National Laboratories 01/26/2016
Issued
Technology Status
Development StageAvailabilityPublishedLast Updated
PrototypeAvailable - Various licensing and partnering options are available. Please contact the Intellectual Property Department to discuss.01/17/201310/31/2016

Contact SNL About This Technology

To: Technology Inquiries<ip@sandia.gov>