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Process for producing 8-fluoropurines

United States Patent

5,861,503
January 19, 1999
View the Complete Patent at the US Patent & Trademark Office
An efficient, regiocontrolled approach to the synthesis of 8-fluoropurines by direct fluorination of purines with dilute elemental fluorine, or acetyl hypofluorite, is provided. In a preferred embodiment, a purine compound is dissolved in a polar solvent and reacted with a dilute mixture of F.sub.2 in He or other inert gas.
Barrio; Jorge R. (Agoura Hills, CA), Satyamurthy; Nagichettiar (Los Angeles, CA), Namavari; Mohammad (Los Angeles, CA), Phelps; Michael E. (Encino, CA)
The Regents of the University of California (Oakland, CA)
08/ 846,424
April 30, 1997
ACKNOWLEDGMENT OF GOVERNMENT SUPPORT This invention was made with government support under Grant No. DE-FC0387-ER60615, awarded by the Department of Energy. The government has certain rights in the invention.