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Cyanine dyes with high-absorbance cross section as donor chromophores in energy transfer labels

United States Patent

5,853,992
December 29, 1998
View the Complete Patent at the US Patent & Trademark Office
Cyanine dyes are used as the donor fluorophore in energy transfer labels in which light energy is absorbed by a donor fluorophore and transferred to an acceptor fluorophore which responds to the transfer by emitting fluorescent light for detection. The cyanine dyes impart an unusually high sensitivity to the labels thereby improving their usefulness in a wide variety of biochemical procedures, particularly nucleic acid sequencing, nucleic acid fragment sizing, and related procedures.
Glazer; Alexander N. (Orinda, CA), Mathies; Richard A. (Moraga, CA), Hung; Su-Chun (Richmond, CA), Ju; Jingyue (Redwood City, CA)
The Regents of the University of California (Oakland, CA)
08/ 726,178
October 4, 1996
GOVERNMENT RIGHTS This invention was made with federal support from the Department of Energy, contract number DE-FG03 -91ER61125. The United States Government has certain rights in this invention.