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Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

United States Patent

5,843,993
December 1, 1998
View the Complete Patent at the US Patent & Trademark Office
A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.
Katti; Kattesh V. (Columbia, MO), Berning; Douglas E. (Columbia, MO), Volkert; Wynn A. (Columbia, MO), Ketring; Alan R. (Columbia, MO)
The Curators of the University of Missouri (Columbia, MO)
08/ 818,078
March 14, 1997
GRANT REFERENCE The research carried out in connection with this invention was supported in part by a grant from the United States Department of Energy DOE-DE-FG02-89ER60875. The Government has certain rights in the inventions .