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Hydroxyalkyl phosphine gold complexes for use as diagnostic and therapeutic pharmaceuticals and method of making same

United States Patent

December 1, 1998
View the Complete Patent at the US Patent & Trademark Office
A complex and method for making same for use as a diagnostic or therapeutic pharmaceutical includes a ligand comprising at least one hydroxyalkyl phosphine donor group bound to a gold atom to form a gold-ligand complex that is stable in aqueous solutions containing oxygen, serum and other body fluids.
Katti; Kattesh V. (Columbia, MO), Berning; Douglas E. (Columbia, MO), Volkert; Wynn A. (Columbia, MO), Ketring; Alan R. (Columbia, MO)
The Curators of the University of Missouri (Columbia, MO)
08/ 818,078
March 14, 1997
GRANT REFERENCE The research carried out in connection with this invention was supported in part by a grant from the United States Department of Energy DOE-DE-FG02-89ER60875. The Government has certain rights in the inventions .