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Optical reaction cell and light source for [18F] fluoride radiotracer synthesis

United States Patent

5,808,020
September 15, 1998
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Apparatus for performing organic synthetic reactions, particularly no-carrier-added nucleophilic radiofluorination reactions for PET radiotracer production. The apparatus includes an optical reaction cell and a source of broadband infrared radiant energy, which permits direct coupling of the emitted radiant energy with the reaction medium to heat the reaction medium. Preferably, the apparatus includes means for focusing the emitted radiant energy into the reaction cell, and the reaction cell itself is preferably configured to reflect transmitted radiant energy back into the reaction medium to further improve the efficiency of the apparatus. The apparatus is well suited to the production of high-yield syntheses of 2-[.sup.18 F]fluoro-2-deoxy-D-glucose. Also provided is a method for performing organic synthetic reactions, including the manufacture of [.sup.18 F]-labeled compounds useful as PET radiotracers, and particularly for the preparation of 2-[.sup.18 F]fluoro-2-deoxy-D-glucose in higher yields than previously possible.
Ferrieri; Richard A. (Patchogue, NY), Schlyer; David (Bellport, NY), Becker; Richard J. (Islip, NY)
Associated Universities, Inc. (Washington, DC)
08/ 694,398
August 12, 1996
This invention was made with Government support under contract number DE-AC02-76CH00016, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.