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Reduction of diffusional defocusing in hydrodynamically focused flows

United States Patent

5,799,682
September 1, 1998
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
An analyte fluid stream with first molecules having relatively low molecular weight and a corresponding high coefficient of diffusion has reduced diffusional defocusing out of an analyte fluid stream. The analyte fluid stream of first molecules is associated with second molecules of relatively high molecular weight having a relatively low coefficient of diffusion and a binding constant effective to associate with the first molecules. A focused analyte fluid stream is maintained since the combined molecular weight of the associated first and second molecules is effective to minimize diffusion of the first molecules out of the analyte fluid stream.
Affleck; Rhett L. (Lawrenceville, NJ), Demas; James N. (Charlottesville, VA), Goodwin; Peter M. (Jemez Springs, NM), Keller; Richard (Los Alamos, NM), Wu; Ming (Middle Island, NY)
The Regents of the University of California (Los Alamos, NM)
08/ 758,738
December 6, 1996
This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.